For all my MTHFR mutation followers and friends: Anyone out there doing a CBS mutation protocol that is working for them? If so, please let me know any protocal, supplements, or diet changes that have helped. I’m going to be writing an expanded post with my treatment plan soon but I sure am having some problems getting my methylation going again. Basically I’m doing this:
CBS Support: molybdenum, charcoal 2-3x week, low “free thiol” sulfur diet for over 2 months now, limited animal protein (3-5oz/day), no grains/potatoes right now (still mostly GAPS/paleo diet).
Short cycle (BHMT mutation) support: GABA-calm (Yasko), GABA, Equilibrate (TMG, L-theanine, 5HTP, L-tryosine, methionine combo. It has a small amount of B6 (20mg) so I’m hoping it won’t upregulate CBS too much)
Methylation support: small amount of methyl B12, hydroxyB12 drop, lithium, homeopathic detox drops, methylated multivitamin formula
Nutrition general: ATP fuel (Vit 3, L-carnitine, CoQ10, mitochondrial support), zinc, digestive enzymes, vit C, probiotics, fish oils
Yasko results: MTHFR A1298C+, CBS 699T++, MTRR ++, COMT-, VDR Taq +, BHMT 2,4,8 +, MAOA +
I’d love to hear what others are taking that is helping. Also what foods seem to make things worse. There is so much confusion on eating a low sulfur diet vs a low free thiol sulfur diet. Also different opinions exist on Ammonia support for CBS++
2015 UPDATE: After a year on a low sulfur diet, along with moderate daily doses of molybdenum, I feel like I’ve got a good hold on the sulfur issue. I just avoid high sulfur foods most of the time, keep my methylation pathways clear with homeopathics, methylfolate and B12. I think stress is the biggest factor that affects this pathway as stress directly affects ability to drain anything that is unwanted from the body. So from now how my first advice of what to take for sulfur/mthfr issues is a “chill pill” 🙂 We can affect our mutations most with epigenetic approaches, not hypervigilant research trying to “fix” our defects.